Christ Carrying the Cross, 1505 by Titian

The painting is mentioned in several historical documents, since it has been the subject of veneration and devotion, due to its alleged miraculous properties. It was originally located in the church of San Rocco, annexed to the eponymuous Scuola where it is now, although it is unknown if it was on a pillar near the high altar or in a side chapel.

The attribution of the work has been disputed since the very 16th century: Giorgio Vasari in both the first (1550) and second (1658) edition of his Lives assigns it to Giorgione and Titian at the same time. Further, both Titian and Giorgione had relationships with the guild which held the church and the Scuola; Giorgione was a friend of painter Vincenzo Catena, a member of the guild.

The work's composition inspired numerous painters in Veneto and Lombardy, such as Lorenzo Lotto, Giovanni Bellini and Andrea Solario.

Jesus is portrayed with a cross on his shoulder, on a dark background, while an executioner is holding a noose on his neck. At the side are two secondary figures. Jesus, with a doleful expression, is looking towards the seer. The profile of the executioner and of the side figures were perhaps inspired by drawings of Leonardo da Vinci, which would be part of Venetian collections at the time. Although the subject of Christ Carrying the Cross had long been a standard one in Italian art, Titian was following a type of "close-up" composition that had only recently been introduced to Northern Italy, from German or northern European examples.

The painting features elements which were typical of both Titian and Giorgione: the sfumato contour of the figures and the inhomogeneous colors were common in the latter's works, while the robustness of the characters and their active participation to the event (differently than the quasi-dreaming contemplation of Giorgione) are a Titian feature.